Troopers said I-85 North was closed near mile marker 22 in Anderson County Saturday morning due to a jackknifed semi.
The crash happened just before 10 a.m.
No injuries were reported.
FOX Carolina reported one lane was moving as of 11:40 a.m.
Drivers can take Clemson Boulevard (Exit 19) east to Highway 81 and turn left to return to I-85.